ea0021oc4.3 | Bone and parathyroid | SFEBES2009
Grigorieva Irina
, Mirczuk Samantha
, Gaynor Katie
, Nesbit M Andrew
, Grigorieva Elena
, Wei Qiaozhi
, van der Wees Jacqueline
, Fraser William
, Hough Tertius
, Manley Nancy
, Grosveld Frank
, Thakker Rajesh
Heterozygous mutations of GATA3, a dual zinc-finger transcription factor, cause the hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome. To study the role of GATA3 in parathyroid function we have investigated Gata3+/− mice for hypoparathyroidism. Gata3+/− and Gata3+/+ mice were challenged at weaning with a diet low in calcium (0.001%) and vitamin D (0.0 IU/g). The low calcium-vitamin D diet led to a ...